TITLE:
Quality of Life and Associated Factors in Patients Infected with Hepatitis B and C Virus in a Moroccan Region: A Cross-Sectional Study
AUTHORS:
Diagne Bineta Jho, Abid Hakima, Ibtissam El Harch, Soumaya Benmaamar, Bourkhime Hind, Bahra Nassiba, Baldé Mamadou Saliou, Condé Passy, Nada Otmani, Mohammed El Abkari, Mohamed Amine Berraho, Nabil Tachfouti, Samira El Fakir
KEYWORDS:
Quality of Life, Chronic Hepatitis, Hepatitis B Virus, Hepatitis C Virus, SF12, Health-Related Quality of Life, Morocco
JOURNAL NAME:
Open Access Library Journal,
Vol.9 No.5,
May
27,
2022
ABSTRACT: Introduction: Hepatitis B or C virus infection is one of the most common liver infections leading to altered health-related quality of life (HRQoL) in patients. The goal of this study was to assess the quality of life of patients infected with hepatitis B or C virus and to determine the factors that might be associated with worse outcomes. Methods: A cross-sectional study was conducted in patients aged 18 years and over followed on an outpatient basis at the teaching hospital Hassan II in Fez for hepatitis B or C. These patients were asked to complete the SF-12 questionnaire file which is the short form of the quality measurement scale of life SF-36. Sociodemographic, clinical and economic information was collected. A descriptive analysis was carried out, then a univariate analysis in search of factors associated with quality of life, and finally a multivariate analysis by linear regression was carried out adjusting for possible confounding factors. Results: A total of 94 patients whose mean age was 55.69 ± 13.25 years met the inclusion criteria. The physical quality of life was altered with an average of 41.98 ± 12.67. Hepatitis C virus infection (β = -6.802; 95% CI = (-12.05; -1.55)), cirrhosis (β = -6.947, 95% CI = (-12.04; -1.84)) and lack of employment (β = -8.48, 95% CI = (-13.18; -3.77)) were the factors associated with poor quality of life. The mental quality of life (MCS) was also altered with an average of 46.32 ± 12.84. In multivariate analysis we found that participants with hepatitis C (β = 7.444, 95% CI = (2.14; 12.74)), unemployed (β = 6.697, 95% CI (2.28; 11.11)) and having received treatment (β = 8.295, 95% CI (2.95; 13.63) had a better mental quality of life, while alcoholics had an impaired mental quality of life (β = -8.105, 95% CI (-15.28; -0.92)). Conclusion: Quality of life is altered in patients with chronic hepatitis regardless of type.