Bender, F.C., Reymond, M.A., Bron, C. and Quest, A.F. (2000) Caveolin-1 Levels Are Down-Regulated in Human Colon Tumors, and Ectopic Expression of Caveolin-1 in Colon Carcinoma Cell Lines Reduces Cell Tumorigenicity. Cancer Research, 60, 5870-5878.

has been cited by the following article:

• TITLE: Caveolin-1 Inhibits Proliferation and Migration of Gastric Cancer Cell via Inactivating BMI-1

  AUTHORS: Jun Wang, Shasha Liu

  KEYWORDS: Caveolin-1, Proliferation, Migration, BMI-1, GC

  JOURNAL NAME: Open Journal of Pathology, Vol.12 No.3, May 12, 2022

  ABSTRACT: Objective: To investigate the effect of Caveolin-1on the proliferation and migration ability in gastric carcinoma cells MGC-803 and its mechanism. Methods: Plasmid DNA pcDNA3.1-Cav1 was extracted by extracted kits, and transfected Cav-1 gene sequences were found. The expression levels of Cav-1 protein were detected by Western blot. And the proliferation was analyzed by CCK8 assay. The effect of Cav-1 on migration was detected by wound healing. The expression levels of BMI-1 protein were detected by western blot. Results: 1) Western Blot showed that the expression levels of Cav-1 were higher in MGC-803/Cav-1 than control group, P 0.05. Wound healing showed, that the migration ability of MGC-803/Cav-1 fell off, P Conclusion: Caveolin-1 can inhibit the proliferation and migration ability of gastric carcinoma cells and its mechanism may relate to BMI-1.