TITLE:
Vitamin D and Parathyroid Hormone Profiles in Living Kidney Failure Patients in Côte d’Ivoire
AUTHORS:
Maxime Roméo Kouadio, Lydie Boyvin, Gnogbo Alexis Bahi, Assieoussou Jean-Luc N’Guessan, Cackouoh Carole Constance Koudou, Souleymane Méité, Allico Joseph Djaman
KEYWORDS:
25-Hydroxyvitamin D, Chronic Renal Failure, Côte d’Ivoire, Secondary Hyperparathyroidism, Parathyroid Hormone
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.12 No.2,
March
24,
2022
ABSTRACT: Introduction: Abnormalities in mineral and bone metabolism, particularly
phosphocalcic metabolism, are common in renal failure and are associated with a
significant morbidity and mortality. The regulation of phosphocalcic metabolism
is subject to a particularly precise and complex control of parathormone (PTH)
and vitamin D. Assessment of vitamin D and parathyroid hormone concentrations
would help to improve the medical management of patients with chronic kidney
disease and ensure a better quality of life. Methods: The study population consisted of 138 individuals including 46 non- dialysis
renal failure patients, 46 chronic hemodialysis patients and 46 non- renal
failure volunteers to serve as controls. Serum Parathyroid hormone and Vitamin
D concentrations were measured using the Vidas automated system. Results: 25-hydroxyvitamin D concentrations in controls (65 ± 2.41 nmol/L) and
dialysis patients (70 ± 3.03 nmol/L) were significantly higher than those in
CKD patients (48 ± 3.34 nmol/L). On the other hand, the mean values of
Parathyroid hormone in dialysis patients (312 ± 36.22 pg/mL) and CKD patients
(117 ± 10.68 pg/mL) were very high compared to that in controls (25 ± 2.34
pg/mL). Conclusion: Secondary hyperparathyroidism is common in renal failure. Parathyroid
hormone and 25-hydroxyvitamin D assays would be adequate for better management
of chronic renal failure.