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https://doi.org/10.1038/s41598-021-96232-8

has been cited by the following article:

• TITLE: Reaction-Diffusion Algorithm for Quantitative Analysis of Periodic V-Shaped Bundles of Hair Cells in the Inner Ear

  AUTHORS: Hiroto Shoji, Ryo Iwamoto

  KEYWORDS: Reaction-Diffusion, Turing, Triangle, Inner Ear

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.3, March 23, 2022

  ABSTRACT: Columnar outer hair cells of the inner ear form V-shaped bundles, which are arranged in three rows in the cochlea. If the formation of these V-shaped bundles is disturbed, sensorineural hearing loss occurs. To quantify the distribution of V-shaped bundles, the use of a Turing-type reaction-diffusion (RD) system, including anisotropic diffusion, should be considered. We found that a periodic triangle pattern appears based on the anisotropy in the RD system. Then, using the proposed RD system, the image of the V-shaped bundle was examined. The results showed that the correlation between the RD pattern and V-shape bundles not only classifies the experimental result but also significantly differs in the number of directional changes in a set of V-shape bundle. Therefore, this process can help quantify the images of V-shaped bundles.