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has been cited by the following article:

• TITLE: Creutzfeldt Jacob’s Disease: A Senegalese Observation

  AUTHORS: Ahmadou Bamba Mbodji, Alassane Mamadou Diop, Momo Banda Ndiaye, Serigne Saliou Mbacke, Khalifa Ababacar Mbaye, Rokhaya Diagne, Ibrahima Niang, Ndiaga Matar Gaye, Maouly Fall, Adjaratou Sow, Anna Basse, Lala Bouna Seck, Moustapha Ndiaye, Amadou Gallo Diop

  KEYWORDS: Creutzfeldt-Jakob Disease, Protein 14-3-3, Prion Disease, Rapidly Progressive Dementia

  JOURNAL NAME: Neuroscience and Medicine, Vol.13 No.1, March 7, 2022

  ABSTRACT: Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.