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has been cited by the following article:

• TITLE: The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on Pseudomonas aeruginosa in Vitro

  AUTHORS: Jiming Li, Meide Wei, Linghong Wang, Yanbo Wu, Lu Kang, Yan Tang, Huan Zhao, Yubiao Sun

  KEYWORDS: Baicalin, Cefoperazone-Sulbactam Sodium, Combined Use, Pseudomonas aeruginosa, Drug Resistance, Antibacterial

  JOURNAL NAME: Natural Science, Vol.14 No.3, March 7, 2022

  ABSTRACT: Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of Pseudomonas aeruginosa. Method: Pseudomonas aeruginosa strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against Pseudomonas aeruginosa drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P Pseudomonas aeruginosa.