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has been cited by the following article:

• TITLE: Long-Term Prognosis and Predictive Risk Factors for Polyvascular Disease in Patients with Peripheral Arterial Disease

  AUTHORS: Kuniki Nakashima, Hisao Kumakura, Ryuichi Funada, Yae Matsuo, Kimimasa Sakata, Akiko Ichikawa, Toshiya Iwasaki, Shuichi Ichikawa

  KEYWORDS: Polyvascular Disease, Cerebral Infarction, Coronary Heart Disease, Fate of Leg, Peripheral Arterial Disease

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.12 No.1, January 27, 2022

  ABSTRACT: Background: The aim of the current study was to assess fifteen-year life expectancy, cardiovascular events, fate of the limb, and risk factors with or without polyvascular disease in patients with Peripheral Arterial Disease (PAD). Methods: We conducted a prospective cohort study in 1019 PAD patients. The endpoints were Cardiovascular or Cerebrovascular Death (CCVD), All-Cause Death (ACD), Major Adverse Cardiovascular Events (MACE), and Cardiovascular and/or Limb Events (CVLE). Results: The patients who died were539 (52.9%) during follow-up periods. The rate of CCVD was 50.5% (n =272). In multiple regression analysis, the number of affected arteries had correlations with estimated Glomerular Filtration Rate (eGFR), HDL-cholesterol,Ankle Brachial Pressure Index (ABI), and diabetes (p cholesterol, and diabetes (p CVD and CHD) was correlated with ABI, eGFR, HDL-cholesterol, and diabetes (p The number of affected arteries had significant correlations withCCVD, ACD, MACE, and CVLE (p 0.05). In Cox multivariate analyses, age, Critical Limb Ischemia (CLI), eGFR, albumin, C-Reactive Protein (CRP), Body MassIndex (BMI), CVD, and CHD were related to CCVD (p Conclusions: Polyvascular disease was independently associated with fifteen-year mortality,cardiovascular events, and the fate of the limb with diverse risk factors in PAD patients.