Wilson, R.D., Davies, G., Désilets, V., et al. (2003) The Use of Folic Acid for the Prevention of Neural Tube Defects and Other Congenital Abnormalities. Journal of Obstetrics and Gynaecology Canada, 25, 959-965.
https://doi.org/10.1016/S1701-2163(16)30248-1

has been cited by the following article:

• TITLE: Epidemiological and Clinical Aspects of Congenital Hydrocephalus in the Neonatal Department of Gabriel Touré Teaching Hospital Bamako Mali

  AUTHORS: Hawa G. Diall, Oumar Coulibaly, Youssouf Sogoba, Hatouma Sylla, Yacouba A. Coulibaly, Fatoumata L. Diakité, Lala N. Sidibé, Ibrahima Ahamadou, Leyla Maiga, Abdoul K. Doumbia, Pierre Togo, Adama Dembélé, Mohamed E. Cissé, Fousseini Traoré, Belco Maiga, Karamoko Sacko, Djeneba Konaté, Bourama Kané, Oumou Koné, Guedjouma Dembélé, Abdoul A. Diakité, Drissa Kanikomo, Fatoumata D. Traoré, Mariam Sylla, Boubacar Togo

  KEYWORDS: Newborn, Congenital Hydrocephalus, Mortality, Gabriel Toure

  JOURNAL NAME: Open Journal of Pediatrics, Vol.12 No.1, January 7, 2022

  ABSTRACT: Objective: The aim of our work was to access the epidemiological and clinical aspects of congenital hydrocephalus in the pediatrics department of Gabriel Touré teaching Hospital Bamako. Methods: We conducted a retro and prospective study that ran from January, 1st 2018 to July, 30, 2019. All newborns of 72 hours of life or less with hydrocephalus confirmed by sonography or CT scan were enrolled in this study. Results: During the study period, 5416 patients were hospitalized in the neonatology department. Among them, 39 patients (0.72%) presented congenital hydrocephalus and congenital infectious causes accounted for 25.6%. The sex ratio (M/F) was 1.78. Mothers were housewives and not educated in 79.5% and 64.1% respectively. The parents resided outside Bamako in 61.5% of cases. Prenatal consultations were conducted in 32 patients (82%). Consanguinity between the 2 parents was present in 38.5%. The antenatal diagnosis was made in 8 patients (20.5%). Vaginal delivery was the main mode of birth (67%). The average birth weight was 2930 g (1000 to 5400 g) and the average head circumference was 37.82 cm (26 - 55 cm). In 87.2% of cases, newborns were eutrophic. The main clinical signs were bulging anterior fontanel (46.2%), sunset gaze (20.5%), prominent forehead (48.7%), reduced face (20.5%), enlarged cranial sutures (43.6%), macrocrania (25.6%). Transfontanellar ultrasound and CT scan were performed in 51.3% and 48.7% of cases respectively. Associated malformations were spina bifida in 30.8% of cases followed by Dandy Walker malformation (5.1%), and omphalocele (2.5%). The neurological signs were diminished neonatal reflexes (51.3%), hypotonia (30.8%), motor deficit (38.4%), intracranial hypertension (25.6%), seizures 10.25% and psychomotor delay (43.6%). Surgery was performed in 8 neonates (20.5%). Ventriculo-peritoneal shunt (VPB) was the main treatment. Postoperative complications were infectious (37.5%) and mechanical complications (12.5%). The postoperative mortality rate was 12.5%.The overall mortality was 13 cases (33.3%). Conclusion: The hospital frequency of congenital hydrocephalus in our environment seems low but does not reflect reality.