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has been cited by the following article:

• TITLE: The Effect of Momordica charantia on Ovarian Ischemia-Reperfusion

  AUTHORS: Asir Firat, Deveci Engin, Gokalp Ozkorkmaz Ebru, Şahin Fırat, Ermiş Işılay Sezen

  KEYWORDS: Follicles, Histology, Ischemia, Momordica charantia, Ovary, Reperfusion

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.9 No.12, December 2, 2021

  ABSTRACT: Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate the effects of Momordica charantia (MC) on ovarian tissue injury induced by ovarian ischemia-reperfusion. Twenty-four rats were assigned to three groups: control group, ischemia-reperfusion (I/R) group and IR + MC group. 600 mg/kg MC extract were given rats via orogastric route. 3-hour ischemia and 3-hour reperfusion were performed for IR protocol. At the end of experiment, ovarian tissues were excised, fixed in zinc-formalin and processed for routine paraffin wax tissue embedding. Sections were stained with hematoxylin and eosin. Ovarian sections of control group showed regular histological appearance. In ovarian sections of I/R group, hemorrhage, fibrin accumulation, mononuclear cell infiltration and degenerated follicles were observed. I/R + MC group showed improved histopathology caused by I/R injury. We think that MC extract may protect ovarian tissue integrity and its histological structures.