TITLE:
Pattern of Recurrence in Radically Treated Triple Negative Breast Cancer Patients
AUTHORS:
Aravindh Sivanandan Anand, Annie Joseph, Antony Stanley
KEYWORDS:
Triple Negative Breast Cancer, Recurrence, Pattern of Failure, Locoregional, Distant Metastasis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.11,
November
19,
2021
ABSTRACT: Background: In India approximately 20% of the patients with breast cancer are triple
receptor negative. Owing to the aggressive nature and shorter disease-free
survival judicious follow up and identification of failure pattern will benefit
the patient. Similar studies have been conducted among non-Hispanic population
and in China. This study aims to identify failure pattern in radically treated
breast cancer patients who are triple receptor negative among Indian
population. Methods: This prospective observational study was conducted
in the Department of Radiation Oncology, a tertiary cancer centre in Kerala,
India. The objective was to record the pattern of recurrence among triple
negative breast cancer patients who completed their planned radical treatment.
171 patients with triple negative breast cancer were included in the study.
Patients who completed the planned radical treatment were kept under regular
follow up. Details of clinical examination and investigations during the follow
up were recorded periodically. Results: Out of 171 patients 30 patients
had a recurrence of disease. Median age of the population was 53 years. Among
the 30 patients who had a recurrence, 16 patients (53%) had systemic relapse and 14 patients (47%)
had locoregional relapse. Lung was found to be the most common site of distant
metastasis (37%). Ipsilateral chest wall was found to be the most common site
of locoregional relapse (50%). 6 months disease free survival was found to be
91.8% and 1-year disease free survival was found to be 70.2%. Conclusion:
Among radically treated triple negative breast cancers relapses, systemic
recurrence was more than locoregional recurrences.