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https://doi.org/10.1093/oxfordjournals.humrep.a136297

has been cited by the following article:

• TITLE: ICSI with All Oocytes Recurrent Metaphase I Characterized by Absence Perivitelline Space

  AUTHORS: Yan Jiang, Ge Song, Jingchuan Yuan, Xuhui Zhang

  KEYWORDS: ICSI, Recurrent MI Oocyte Arrest, AOA, Ionomycin

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.11 No.9, September 6, 2021

  ABSTRACT: Previous cases reported recurrent all oocytes in repeated cycles were arrested at MI failed to mature after culture and ICSI resulted in total nonfertilization. Ionomycin induced first PB extrusion in patients with recurrent maturation-resistant MI oocytes. ICSI combined with assisted oocyte activation (AOA) on MII oocytes matured in vitro resulted in abnormal fertilization with no further embryo cleavage potential. The objective of this work was to research if AOA helpful to fertilization for recurrent maturation-resistant MI oocytes. In this case, patient both cycles retrievaled immature MI oocytes characterized by absence perivitelline space (APVS). In the second cycle, ionomycin was used for AOA after MI oocyte perfomed ICSI, no fertilization again.