TITLE:
Estimation of Glomerular Filtration Rate: Which Formula to Apply in G-Spot Subjects Aged 1 - 17 Years?
AUTHORS:
Hamadoun Yattara, Djibril Mamadou Couliblay, Nouhoum Coulibaly, Pamela Samiza, Seydou Sy, Arboncana Maiga, Djeneba Diallo, Moustapha Tanagra, Alkaya Touré, Magara Samaké, Niagalé Diakité, Aboubacar Sidiki Fofana, Ibrahim Izetiengou Maiga, Sahare Fongoro
KEYWORDS:
Glomerular Filtration Rate, Reference Value, Young Subjects
JOURNAL NAME:
Open Journal of Nephrology,
Vol.11 No.3,
August
31,
2021
ABSTRACT: Introduction: Morbidity and mortality in paediatric practice is dominated in Africa by malaria, diarrhoeal diseases and acute respiratory infections. Aim: In order to evaluate the Glomerular Filtration Rate (GFR) with the formulas commonly used by medical laboratories, we proposed to undertake this study. Patients and Method: This was a descriptive, prospective and cross-sectional study conducted at the PA and KA medical biology laboratory in Bamako Hamdalaye ACI 2000 in collaboration with the medical biology and hospital hygiene laboratory service at the Point G University Hospital. Results: During the study period, we recruited 360 subjects, 189 of whom were male (52.5%) and 171 female (47.5%). The mean age was 8.75 ± 4.8 years with extremes of 1 and 17 years. Subjects aged 15 to 17 years were the most numerous. The reference means GFR of the subjects according to age was with the SCHWARTZ formula 179.16 ± 50.47 with extremes of 173.93 and 184.39; with CKD-Epi 37.63 ± 11.25 with extremes of 36.46 and 38.79; with MAYO 107.87 ± 18.11 with extremes of 105.99 and 109.75 and MDRD 350.83 ± 251.15 with extremes of 324.79 and 376.86. Conclusion: The Mayo formula showed a better distribution around the mean than other formulas for estimating the glomerular filtration rate.