TITLE:
Persistence of Anti-SARS-CoV-2 IgM Antibody up to 8 Months Post-COVID-19
AUTHORS:
Carlos David A. Bichara, Ednelza S. G. Amoras, Gergiane L. Vaz, Cléa N. C. Bichara, Isabella P. C. Amaral Amaral, Antonio C. R. Vallinoto
KEYWORDS:
COVID-19, SARS-CoV-2, Antibodies, IgM, Persistence
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.10 No.9,
August
31,
2021
ABSTRACT: Here, we present a longitudinal analysis of two patients who recovered from COVID-19 more than 8 months prior but showed persistent serological detection of anti-SARS-CoV-2 IgM. We still do not know the exact reason for this prolonged persistence of IgM in these patients. To our knowledge, these are the first reports of IgM persistence in the context of SARS-CoV-2 infection and point to the need for no longer using IgM as a diagnostic criterion for acute or recent COVID-19. One should opt for gold standard molecular methodologies due to their high sensitivity and specificity.