Emilsson, V., Gudmundsson, F.E., Aspelund, T., Jonsson, B.G., Gudjonsson, A., Launer, L.J., et al. (2020) Antihypertensive Medication Uses and Serum ACE2 Levels ACEIs/ARBs Treatment Does Not Raise Serum Levels of ACE2. medRxiv. (Preprint)
https://doi.org/10.1101/2020.05.21.20108738

has been cited by the following article:

• TITLE: An Analysis of Blood Pressure Situations in Japan Using the Large-Scale Medical Checkup Dataset

  AUTHORS: Kazumitsu Nawata

  KEYWORDS: Blood Pressure, Hypertension, SBP and DBP, Medical Checkups, Antihypertensive Drugs

  JOURNAL NAME: Health, Vol.13 No.7, July 15, 2021

  ABSTRACT: Background: The high blood pressure (BP) or hypertension is a widely prevalent disease and its costs are very high, and many studies about the relationships between BP and health conditions have been done. We need to know the precise distributions of BP and factors affecting BP. Data and Methods: The distributions of BP are analyzed using 12,877,653 observations obtained from the JMDC Claims Database. The factors that may affect the BP are analyzed by the regression models using 4,615,346 observations. Results: The averages of systolic BP (SBP) and diastolic BP (DBP) are 120.4 and 74.2 mmHg with standard deviations of 15.9 and 11.3 mmHg, respectively. Among the nonmodifiable factors, age and gender are important factors. Among the modifiable factors, variables related to obesity are important risk factors. Taking antihypertensive drugs makes SBP and DBP 13.4 mmHg and 7.8 mmHg lower. Conclusion: The criteria of BP should be carefully determined considering age and gender. The effects of age may be a little different for SBP and DBP. It is necessary to use the proper model to evaluate the effect of antihypertensive drugs correctly. Limitations: The dataset is observatory. Although there are various types of treatment methods and antihypertension drugs, their effects are not evaluated.