TITLE:
Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients
AUTHORS:
Kandji Pape Matar, Djite Moustapha, Barry Nene Oumou Kesso, Sagne Rene Ngor, Thioune Ndeye Mareme, Mbacke Ndoumbé Mame, Ndour El Hadji Malick, Gueye-Tall Fatou, Lopez-Sall Philomene, Cisse Aynina, Diop Pape Amadou, Gueye Papa Madieye
KEYWORDS:
Sickle Cell Disease, Metabolic Syndrome, Uric Acid, IDF 2009
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.3,
June
17,
2021
ABSTRACT: The objective of this study was to assess the association between uric
acid and the metabolic syndrome and its
components in homozygous sickle cell patients. This is a prospective
case/control study of sickle cell SS patients. Each patient
was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to
International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago,
Illinois, USA). Data were collected with Excel 2016 software and statistical
analysis was done using XLSTAT 2019 software. Student’s T test was
used to compare means and a p-value less
than 0.05 was considered significant. The study
population consisted of 100 homozygous sickle cell patients with an average age
of 26 years with a sex ratio of 0.58. The prevalence of metabolic syndrome in
our population according to the IDF 2009 was 2%. In our study 28% of patients
presented with hyperuricemia. Uricaemia was significantly elevated in patients
with components of the metabolic syndrome, in particular in 33% of patients
with a large waist circumference, in 25% of hypertensive patients, in 50% of
patients with hypertriglyceridemia and in 60% of patients with hypertriglyceridemia
and low HDL-cholesterol levels. Significant correlations were found between
uricemia and certain components of the metabolic syndrome, in particular the
level of triglycerides (r = 0.31, p = 0.002), blood sugar (r = 0.16; p = 0.012),
around size (r = 0.071; p ≤ 0.05), HDL-Cholesterol (r = ﹣0.01; p = 0.018), PAS (r = 0.076; p = 0.035) and PAD (r = ﹣0.18; p =
0.0015).