Ponce-Coria, J., San-Cristobal, P., Kahle, K.T., Vazquez, N., Pacheco-Alvarez, D., de Los Heros, P., et al. (2008) Regulation of NKCC2 by a Chloride-Sensing Mechanism Involving the WNK3 and SPAK Kinases. Proceedings of the National Academy of Sciences of the United States of America, 105, 8458-8463.
https://doi.org/10.1073/pnas.0802966105

has been cited by the following article:

• TITLE: Sequential Combination Diuretic-Therapy for Massive Fluid Overload in Furosemide-Refractory Patients with Diabetic Kidney Disease

  AUTHORS: Kamel El-Reshaid, Shaikha Al-Bader

  KEYWORDS: Aldactone, Diabetes Mellitus, Echocardiography, Fluid Overload, Furosemide, Hydrochlorothiazide, Kidney Disease, Metolazone, Spironolactone

  JOURNAL NAME: Open Journal of Nephrology, Vol.11 No.2, June 7, 2021

  ABSTRACT: Patients with renal disease are at risk of fluid overload which escalates as the disease progresses. In the present study, we evaluated the efficacy of sequential combination diuretic-therapy (SCDT) in management of massive fluid overload in Furosemide-refractory renal patients. The added diuretics were Spironolactone 25 mg daily for 3 days, to those without risk of hyperkalemia, followed by Hydrochlorothiazide 25 mg/Metolazone 5 mg daily for 3 more days. Excluded patients were those with 1) acute renal disease, 2) echocardiographic evidence of: a) left ventricular ejection fraction