TITLE:
Factors Associated with Death among Tuberculosis Patients in Dakar
AUTHORS:
Moustapha Diop, Papa Samba Ba, Jean Augustin Diegane Tine, Ndèye Maguette Fall, Tracie Youbong, Mouhamadou Ndiaye, Ndèye Mouminatou Mbaye, Mouhamed Bouye Nestor Diatta, Alassane Sarr, Sokhna Walo Ndiaye, Ibrahima Cisse, Louise Fortes Degenonvo, Abdourahmane Niang, Adama Faye, Moussa Seydi
KEYWORDS:
Tuberculosis, Death, Associated Factors, Dakar
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.11 No.2,
April
19,
2021
ABSTRACT: Introduction-Objective: Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide. The predictors of mortality due to TB are rarely evaluated in Senegal. The aim of our study was to identify factors associated with related TB death in two treatment centers in Dakar, Senegal. Method: We conducted a prospective descriptive-analytical study dealing with TB patients followed in the Department of Infectious and Tropical Diseases at FANN Teaching Hospital and Dakar Principal Hospital and in the Department of Pulmonology at Dakar Principal Hospital from March 1st, 2019 to February 29th, 2020. Univariate and multivariate logistic regressions were performed to identify the associated factors of death. Results: Two hundred eighty-two patients in the Department of Infectious and Tropical Diseases at FANN teaching hospital (57%), in the Department of Infectious and Tropical Diseases at Dakar Principal Hospital (31%), and in the Department of Pulmonology at Dakar Principal Hospital (12%) were included in the study. The mean age was 39 ± 16 years and the male to female ratio was 2.2. Isolated pulmonary TB, isolated extrapulmonary TB, and both pulmonary and extrapulmonary TB were present in 33.3%, 30.5% and 36.2% of cases, respectively. Twenty-two patients died, corresponding to a mortality rate of 7.8%. Factors independently associated with death were age ≥ 60 years (26.2 [3.6 - 191.2]) compared to 16 - 40 years’ age group, HIV infection (7.2 [1.4 - 36.9]), neurological localization of TB (13.19 [3.2 - 54.3]), and hemoglobin level Conclusion: Tuberculosis remains a fatal disease despite therapeutic advances. Better knowledge of associated factors of death from TB may help to reduce its mortality.