Article citationsMore>>
Bouattour, A., Fakhfakh, M., Abid, S., Paquin, L., Le Guével, R., Corlu, A., Ruchaud, S., Bach, S., Ammar, H., et al. (2017) Microwave Assisted a Practical Synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione Derivatives and Exploration of Their Biological Activities. Arkivoc, 4, 291-302.
https://doi.org/10.24820/ark.5550190.p010.040
has been cited by the following article:
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TITLE:
3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines
AUTHORS:
Ali Bouattour, Mehdi Fakhfakh, Souhir Abid El-Gharbi, Majdi Abid, Ludovic Paquin, Rémy Le Guevel, Thierry Charlier, Houcine Ammar, Jean-Pierre Bazureau
KEYWORDS:
2-Iminocoumarin, Tetrazole, Fluorescence, Tumor Cell Lines, HCT 116
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.11 No.1,
March
9,
2021
ABSTRACT: The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by 1H, 13C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC50 15 μM).