Lopez-Angulo, G., Verdugo-Gaxiola, S.E., Montes-Avila, J., Delgado-Vargas, F., et al. (2019) Bioguided Isolation of N-malonyl-(+)-tryptophan from the Fruit of Pithecellobium dulce (Roxb.) Benth. That Showed High Activity against Hymenolepis nana. Natural Product Research, 35, 593-599.
https://doi.org/10.1080/14786419.2019.1590709

has been cited by the following article:

• TITLE: The Dependence of N-Malonyltryptophan Formation in Plants on Water Deficit (Review)

  AUTHORS: Kim Z. Gamburg

  KEYWORDS: Drought Stress, N-Acetyltryptophan, 1-Aminocyclopropane-1-Carboxylic Acid, Indole-3-Acetic Acid, Tryptophan Malonylation

  JOURNAL NAME: Natural Science, Vol.13 No.2, February 26, 2021

  ABSTRACT: Drought stress in plants is accompanied by several metabolic changes. One of them is the appearance of N-malonyltryptophan (MT) during leaf wilting of many species, but there is a significant number of plant species in which the appearance of MT did not occur. Plants of some species were able to synthesize also N-acetyltryptophan (AT). Excised tomato leaves incubated with D-amino acids (including D-Trp) transform them into malonyl- and acetyl-derivatives even without water deficit. However, MT which appeared during water deficit has been shown to contain L-Trp. Amino acid—1-amino-cyclopropane-1-carboxylic acid (ACC) is also malonylated during water deficit, but other L-amino acids were not malonylated. N-malonyl transferases specific for Trp and ACC have been found in several plants. The existence of N-malonyltransferase specific to L-Trp and appeared during water deficit in plants forming MT is supposed, but clear experimental proof has not been obtained yet. Plants can transform MT applied exogenously into Trp and further to indole-3-acetic acid (IAA). But no evidence has been appeared up to now that endogenous MT may be a source of IAA. It is unknown till now why it is necessary for plants of many species to malonylate only Trp during water deficit. How MT metabolized in animals and if it affects them is also unknown. The necessity to use molecular-genetic approaches for the elucidation of the physiological significance of MT formation during water deficit is underlined.