Chabalenge, B., Korde, S., Kelly, A.L., Neagu, D. and Paradkar, A. (2020) Understanding Matrix Assisted Continuous Cocrystallisation Using Data Mining Approach in Quality by Design (QbD). Crystal Growth & Design, 20, 4540-4549. https://doi.org/10.1021/acs.cgd.0c00338

has been cited by the following article:

• TITLE: Optimization of Carbamazepine-Succinic Acid Cocrystal Preparation Using Quality by Design Approach

  AUTHORS: Yingfan Xia, Chengjun Jiang, Jinna Zhang

  KEYWORDS: Quality by Design, Cocrystals, Carbamazepine

  JOURNAL NAME: Open Access Library Journal, Vol.8 No.2, February 24, 2021

  ABSTRACT: The present investigation was aimed at using quality by design approach optimization of cocrystal preparation. The challenge was too many factors affect the final purity and yield. Carbamazepine (CBZ)-succinic acid (SA) was selected as a model cocrystal for this study. A Design of Experiments (DoE) approach, specifically Central Composite Design (CCD) with the aid of Response Surface Methodology (RSM) was used to optimize formulation variables for the synthesis of carbamazepine and succinic acid cocrystals using slurry crystallization. Design was applied for studying the effect of four independent variables (time, molar ratio, temperature, and concentration) on the yield. The experimental outcome indicated that the molar ratio significantly affects the yield of the cocrystal. Further, the optimized formulation was characterized by powder X-ray diffraction. It can be found that within a certain range, all obtained are pure cocrystal.