TITLE:
Physico-Chemical and Microbiological Study for the Stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals
AUTHORS:
Syed Ata ur Rahman, Abdullah Alsaedi, Abdulelah Alhusayni, Abdulmalik Alqurshi, Sameh Ahmed, Yaser M. Alahmadi, Alaa Omer M. Abdullaal, Badr Ahmed A. Taher, El-Sayed E. Habib
KEYWORDS:
Physical Stability, Phenytoin, Extemporaneous Preparation, Chemical Stability, Epilepsy
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.12 No.1,
January
19,
2021
ABSTRACT: Epilepsy
is a chronic and the fourth most common neurological disorder which affects
people of all age groups. Recently research and awareness on epilepsy-related
deaths have rapidly grown over the past two decades. Many previous studies are
attributed to the guidelines that apprise health care professionals in handling
these deaths, but there is a relative scarcity of information accessible for clinicians
and pharmacists who are responsible for manufacturing or preparing the
extemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial
seizures, phenytoin is one of the first-choice drugs. In Saudi Arabian
hospitals, the extemporaneous preparation of phenytoin suspension is common,
but the hot climatic weather in Saudi Arabia possesses stability problems that
should be tackled as the prepared suspension should pass all the stability
tests to ensure uniform dosage of the extemporaneous formulation. In the
current study, the commercial capsules were used to prepare the oral phenytoin
sodium extemporaneous suspension. The physical, chemical and microbiological
stability of phenytoin sodium suspension is analyzed at various temperatures.