Lee, F.J.S., Liu, F., Pristupa, Z.B. and Niznik, H.B. (2001) Direct Binding and Functional Coupling of α-Synuclein to the Dopamine Transporters Accelerate Dopamine-Induced Apoptosis. The FASEB Journal, 15, 916-926. - References

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Lee, F.J.S., Liu, F., Pristupa, Z.B. and Niznik, H.B. (2001) Direct Binding and Functional Coupling of α-Synuclein to the Dopamine Transporters Accelerate Dopamine-Induced Apoptosis. The FASEB Journal, 15, 916-926.
https://doi.org/10.1096/fsb2fj000334com

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AUTHORS: Swati Sharma, Gurudutta U. Gangenahalli, Upma Singh

KEYWORDS: Hematopoietic Stem Cells (HSCs), Signal Transduction, Haematopoiesis

JOURNAL NAME: CellBio, Vol.9 No.3, September 30, 2020

ABSTRACT: Hematopoietic stem cells (HSCs) are tissue-specific cells giving rise to all mature blood cell types regulated by a diverse group of hematopoietic cytokines and growth factors that influences the survival & proliferation of early progenitors and differentiation mechanisms by modulating the functional activities of HSCs. In this study, the functional yet distinctive role of three novel combinations of gene pairs RRAGC & PSMC2; CKAP4 & MANF; and CTR9 & CNTNAP2 have been newly identified. These novel combinations of genes were confirmed and expressed in K562 human leukemic cell line in the presence of cytokine combination (IL-3, FLT-3 and SCF) using RT-PCR and siRNA-mediated gene knock down strategy. This study signifies the synergistic role of gene pairs in different molecular activities like ubiquitination or proteasomal degradation, calcium mobilization, dopamine signaling.

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