TITLE:
Study on the Influence of Saturated Aliphatic Dicarboxylic Acids on the Solubility of Their Norfloxacin Salts
AUTHORS:
Lihua Zhu, Dong Huang, Chengjun Jiang
KEYWORDS:
Norfloxacin, Dicarboxylic Acid, Solubility, Crystal
JOURNAL NAME:
Open Access Library Journal,
Vol.7 No.10,
October
9,
2020
ABSTRACT:
The crystallization of norfloxacin, an antibacterial fluoroquinolone compound, with different saturated aliphatic dicarboxylic acids yields five novel pharmaceutical salts via molecular recognition. In particular, a new norfloxacin-glutaric acid salt was obtained, which was characterized by infrared spectroscopy and powder X-ray diffraction. The effect of pKa on the solubility and dissolution profile of drug salts are investigated in pure water. After the formation of salts, the solubility increases at near neutral pH in all cases. Glutaric acid shows evidence of a good candidate to enhance the solubility of fluoroquinolone drugs for the solubility of 1 is approximately 27.7 times as large as that of norfloxacin in pure water.