TITLE:
Immunohistochemical Biomarkers in Ductal Carcinoma In Situ
AUTHORS:
I. Petrone, F. Resende Rodrigues, P. Valverde Fernandes, E. Abdelhay
KEYWORDS:
Breast Cancer, Ductal Carcinoma In Situ, Immunohistochemistry, Biomarker Proteins, Categorization
JOURNAL NAME:
Open Journal of Pathology,
Vol.10 No.4,
September
21,
2020
ABSTRACT:
Introduction: Breast ductal carcinoma In Situ (DCIS) can be defined as a malignant epithelial proliferation with growth limited by the basal membrane of the ductal epithelium, with no evidence of stromal invasion. There has been a trend of trying to subcategorize DCIS based on cell proliferation assays (Ki67) and the expression of hormone receptors and the human epidermal growth receptor (HER-2) as detected by immunohistochemistry, similar to invasive breast carcinomas (IBC). The aims were to evaluate the expression of breast cancer marker proteins in DCIS by immunohistochemistry to better categorize it. Methods: 46 biopsies from women with DCIS and IBC Luminal A-like were evaluated by immunohistochemistry staining of proteins already known to be biomarkers in IBC. For controls, normal breast tissue from mammoplasty (n = 3) was used. Results: Our results showed an increase of estrogen receptor (ER) and progesterone receptor (PR) expression relative to that in normal tissue samples (p Conclusion: The biology of DCIS is not well understood given the complexity and heterogeneity of the disease, which makes it important to better sub-categorize this tumor, especially considering the possibility of identifying DCIS cases with the potential for recurrence and evolution into IBC.