Article citationsMore>>
Magee, T.V., Ripp, S.L., Li, B., Buzon, R.A., Chupak, L., Dougherty, T.J., Finegan, S.M., Girard, D., Hagen, A.E., Falcone, M.J., Farley, K.A., Granskog, K., Hardink, J. R., Huband, M.D., Kamicker, B.J., Kaneko, T., Knickerbocker, M.J., Liras, J.L., Marra, A., Medina, I. and Flanagan, M.E. (2009) Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections. Journal of Medicinal Chemistry, 52, 7446-7457.
https://doi.org/10.1021/jm900729s
has been cited by the following article:
-
TITLE:
Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides
AUTHORS:
Ouattara Mahama, Coulibaly Songuigama, N’Guessan Deto Jean-Paul
KEYWORDS:
Pharmacochemistry, Erythromycin, Neomacrolide, Ketolide, Neoketolide, Structure-Activity Relationships
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.10 No.3,
August
5,
2020
ABSTRACT: Antibiotic macrolides are experiencing renewed interest in anti-infective therapy since the advent of ketolides. This therapeutic class was introduced in order to broaden the narrow antibacterial spectrum of macrolides and to cope with the emergence of germs resistant to Erythromycin A and its hemisynthetic derivatives or neomacrolides (Clarithromycin, Roxithromycin, Azithromycin, Dirithromycin). From a pharmacochemical point of view, ketolides were first of all obtained by operating chemical modulations on Erythromycin A to obtain the neomacrolides, then, by replacing the neutral sugar (L-cladinose) in C3 by a ketone function coupled with the creation of an oxazolidinone like heterocycle in C11 and C12 in place of the hydroxyls present in these positions (Telithromycin, Cethromycin, Solithromycin). These modulations have enabled the improvement of the chemical stability of ketolides in gastric acid medium and increase their affinity for the ribosomal target, hence the broadening of their spectrum of action towards Gram positive germs including strains resistant to other macrolides and to neomacrolides. Therefore, the objective of this systematic review is to report the various pharmacochemical aspects undertaken since 1952 in the macrolide series based on the structure of Erythromycin A. These aspects will focus on the pharmacomodulations that have led, year after year, to the optimization of stability, the improvement of the pharmacodynamic and pharmacokinetic profile and that have allowed the development of neomacrolides, ketolides and neoketolides, which are today essential in the management of severe bronchopulmonary infections.
Related Articles:
-
C. Tayeh, P. Noun, A. Farah, Y. Khalife, G. Abi Fares, M. Amm, H. Feghali, G. Nicolas, M. C. Fadous Khalife
-
Sanghun Park, Sungsun Choi, Jungim Jang, Eunjeung Kim, Seokju Cho, Jihun Jung, Kyungsik Kim, Sungkyu Park, Musang Kim, Yeonsun Kim, Younghee Oh, Kweon Jung
-
Ellen J. Van Der Gaag, Nicole Van Droffelaar
-
Bernard Mbwele
-
Elham Saad Ellithey Elkhazragy, Saneya Abdel Halim Fahmy, Mona Sayed Mohammad Attaya, Ashraf Mohammad Abd Elrahman