TITLE:
A Rare Case of Holoprosencephalus with Cyclopia
AUTHORS:
Aliou Diouf, Ousmane Thiam, Cheikh C. T. Sarr, Djibril B. Sow, Mamour Gueye, Mame D. Ndiaye, Magatte Mbaye
KEYWORDS:
Holoprosencephalus, Fetus, Cyclopia, Saint-Louis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.10 No.8,
August
3,
2020
ABSTRACT: Cyclopia is a rare genetic defect. It is the most
severe form of alobar holoprosencephaly, characterized by the fusion of the two
orbits and is linked to the lack of development of the frontal bud falling
within the framework of ectroprosopia. Case presentation: This is a case
report of Gravida 3 Para 3, 32 years old and without a history of abortion,
with a history of normal vaginal birth which occurs during labor latency with
active movements of the fetus present and cardiac activity on auscultation with
pinard stethoscope. The uterine height was 32 cm with well palpated fetal
poles. Ultrasound examination confirms the presence of normal cardiac activity
with a poorly responsive fetus. After labor management, she gave birth 3 hours
after admission to the maternity ward of a living newborn male weighing 2800 g
with an Apgar score of 4/10 at the first minute and 2/10 at the fifth minute.
He died 10 minutes later at the maternity hospital of the Saint-Louis regional
hospital center, in northern Senegal. Conclusion: Holoprosencephaly is
certainly rare but remains the most common structural congenital anomaly of the
brain with a complex and multifactorial pathogenesis. Early perinatal diagnosis
and determination of severity are important to inform parents of the
possibilities of a future life. The voluntary termination of pregnancy is an
option but remains prohibited in the country to this day for these indications.