TITLE:
Right and Left Colon Cancer: Clinico-Pathological Features and Treatment Results (South Egypt Cancer Institute Experience)
AUTHORS:
Ashraf Zeidan, Matta Gerges, Shimaa H. Shaban, Mayada Fawzy
KEYWORDS:
Colon Cancer, Right, Left, Tumor Location
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.7,
July
22,
2020
ABSTRACT: Background: Colon cancer (CC) ranks as the third most common cancer worldwide and is
considered the second leading cause of cancer death. Recently, many
international studies have made the observation that right and left colon
cancer have many significant differences regarding clinico-pathological characteristics and primary tumor location has a crucial impact on
treatment outcomes and overall survival. Our study was conducted to verify the
presence of significant differences between right and left colon cancer. Patients
and Methods: This study is a retrospective cohort study which aimed at
comparing right and left colon cancer as regards clinico-pathological data and
treatment results among patients with colon cancer receiving treatment at South
Egypt Cancer Institute (SECI) during the period from 1/2008 to 12/2018. A
sample size of 160 cases of colon cancer patients (80 diagnosed as right colon
cancer and 80 diagnosed as left colon cancer) was randomly selected from our
South Egypt Cancer Institute (SECI)’s tumor registry. Statistical analysis was
done using SPSS program version 20. Difference was considered statistically
significant at P-value Results: Right colon cancer occurred at an older age and was more commonly presented
with abdominal pain while left colon cancer was more commonly presented with
bleeding manifestations. More cases of the right side underwent curative
surgeries whereas more palliative surgeries were performed to left-sided cases.
Left sided cases were associated with a more advanced stage at diagnosis while
right-sided cases were associated with a better response to first-line
chemotherapy. More cases of the left side died due to metastatic disease. On
the other hand, our findings demonstrated no differences between both sides
regarding gender predilection, risk factors, sites of metastases, number of
metastatic organs, histo-pathological examination and grading, response to
second- or third-line chemotherapy, chemotherapy toxicity (hematological or
non-hematological), overall survival, progression-free survival, or
disease-free survival. Conclusion: Primary tumor location of colon
cancer has a significant effect on clinico-pathological characteristics and
treatment outcomes.