Inui, S. and Itami, S. (2007) Perifollicular Pigmentation Is the First Target for Topical Vitamin C Derivative Ascorbyl 2-Phosphate 6-Palmitate (APPS): Randomized, Single-Blinded, Placebo-Controlled Study. The Journal of Dermatology, 34, 221-223.
https://doi.org/10.1111/j.1346-8138.2007.00256.x

has been cited by the following article:

• TITLE: Effect of a Cosmetic Use with 2% Isostearyl-L-Ascorbic Acid Gel for Postinflammatory Hyperpigmentation and Postinflammatory Erythema in Acne Vulgaris

  AUTHORS: Ichiro Kurokawa, Masako Watanabe, Kazuhito Hayashibe

  KEYWORDS: Acne, Vitamin C, Postinflammatory Hyperpigmentation, Postinflammatory Erythema

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.10 No.1, March 23, 2020

  ABSTRACT: Postinflammatory hyperpigmentation (PIH) and postinflammatory erythema (PIE) in acne vulgaris are important and refractory complications for patients with acne vulgaris. To clarify the effects of 2% isostearyl-L-ascorbic acid (ISAA) against PIH and PIE in acne vulgaris, a clinical pilot study with topical 2% ISAA gel was performed in 25 acne patients with PIH and PIE. Topical ISAA gel was applied on the whole face with PIH and PIE in acne vulgaris twice a day for 3 months. Regarding PIH and PIE, investigator’s global improvement rating (IGIR) was evaluated in 7-point scales according to the reduced area of PIH and PIE before and after the study. Remarkable improvement in PIH was observed in 7 patients (28.0%) and in PIE in 12 (48%) of the 25 patients. No adverse reactions were observed during the treatment. Topical ISAA application can be an alternative, non-invasive available treatment for PIH and PIE in acne vulgaris.