Boyden, L.M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M.A., Wu, D., Insogna, K. and Lifton, R.P. (2002) High Bone Density Due to a Mutation in LDL-Receptor-Related Protein 5. The New England Journal of Medicine, 346, 1513-1521.
https://doi.org/10.1056/NEJMoa013444

has been cited by the following article:

• TITLE: LRP5 Affects Homeostasis of the Periodontal Complex

  AUTHORS: Joo-Hyung Kim, Ye-Hyun Kim, Won Hee Lim

  KEYWORDS: LRP5, Periodontal Ligament, Homeostasis

  JOURNAL NAME: Open Journal of Stomatology, Vol.10 No.3, March 17, 2020

  ABSTRACT: Purpose: The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP5) in this process by removing LRP5, and observing the effects of LRP5 depletion on cells of the periodontal structures. Material and Methods: The function of this LRP5 was evaluated by conditional elimination of the LRP5 gene using an Osteocalcin Cre driver. The OCN-Cre; mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. Results: Elimination of LRP5 in the periodontal complex of OCN-Cre;mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament. Conclusion: Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP5 in homeostasis of the periodontal ligament.