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Suh, J.H., Won, K.Y., Kim, G.Y., Bae, G.E., Lim, S.J., Sung, J.Y., Park, Y.K., Kim, Y.W. and Lee, J. (2015) Expression of Tumoral FOXP3 in Gastric Adenocarcinoma Is Associated with Favorable Clinicopathological Variables and Related with Hippo Pathway. International Journal of Clinical and Experimental Pathology, 8, 14608-14618.

has been cited by the following article:

  • TITLE: Association of Elevated Yes-Associated Protein Expression with Gastric Cancer and Its Clinicopathological Features: A Meta-Analysis

    AUTHORS: Qian Peng, Ting Yuan, Xingmei Duan, Jianyou Shi, Lan Bai, Jiying Yu, Lei Zhong

    KEYWORDS: Yes-Associated Protein, Gastric Cancer, Clinicopathological Feature, Meta-Analysis

    JOURNAL NAME: Journal of Biosciences and Medicines, Vol.8 No.2, February 14, 2020

    ABSTRACT: Objectives: To evaluate the difference of YAP-positive expression between GC and adjacent tissues, as well as the association of elevated YAP expression with clinicopathological features of GC. Methods: PubMed, Embase, Web of Science databases and the Chinese National Knowledge Infrastructure (CNKI) were searched from inception up to December 2018. The pooled ORs and corresponding 95% CIs were used to assess the strength of association. The heterogeneity among eligible studies was evaluated by the Q-test and I2 values. The sensitivity analysis was performed by sequential omission of individual studies. Moreover, Begg’s test and Egger’s test were used to evaluate publication bias. Results: A total of 2229 patients from 16 studies were included in this meta-analysis. The results showed that positive YAP expression was closely correlated with GC but not adjacent non-tumor tissue (OR = 8.08, 95% CI = 4.41 - 14.80). Additionally, YAP overexpression was found to be associated with more advanced TNM stage (OR = 2.68, 95% CI = 1.61 - 4.48), deeper invasion depth (OR = 2.05, 95% CI = 1.32 - 3.19), and lymph node metastasis (OR = 1.95, 95% CI = 1.29 - 2.96). No significant correlation was observed between YAP overexpression and degree of differentiation (OR = 1.17, 95% CI = 0.63 - 2.16), as well as gender of patients (OR = 1.12, 95% CI = 0.91 - 1.37) or tumor size (OR = 1.11, 95% CI = 0.82 - 1.49) of gastric cancer. Conclusions: This meta-analysis demonstrated that YAP might be a promising diagnostic marker and even a therapeutic target for gastric cancer.