TITLE:
In-Vivo Anti-Hyperlipidemic Activity and Preliminary Phytochemical Screening of Canephora robusta
AUTHORS:
Kishan Pavani Jankuti, Anusha Govindula, Rajkumar Jampala, Mohammad Arif Pasha, Aligeti Sravan Kumar, Sunayana Soorammagari, Chinnela Satish, Mahankali Naga Ganesh
KEYWORDS:
Anti-Hyerlipidemic, Anti-Obesity, Lipoproteins Hyperlipidemia,
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.10 No.1,
December
11,
2019
ABSTRACT:
The main aim of this study is to determine the anti-hyerlipidemic and anti-obesity activity of Canephora robusta in hyperlipidemia induced rats. Prepared coffee bean extract (GCE) was procured from the market which is unroasted and contains more quantity of caffeine and chlorogenic acid when compared to roasted coffee. Male albino Wister rats are fed with high fat diet (HFD) for weeks to induce hyperlipidemia in rats, which are divided into 4 groups with 4 animals in each group. Test GCBE was given in doses of 200 mg/kg and 400 mg/kg to III and IV groups which are fed with HFD for 30 days. Then blood samples were collected through retro-orbital sinus by capillaries and serum is separated for analysis. The result obtained from lipid profile which includes total cholesterol, triglycerides, very low density lipoproteins, and low density lipoproteins shows the decreased level when compared to the hyperlipidemic control. This shows the significant reduction of total body weight (p