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Ishiyama, S., Imahori, Y., Itami, J. and Hanna, V. (2015) Determination of the Compound Biological Effectiveness (CBE) Factors Based on the Ishiyama-Imahori Deterministic Parsing Model with the Dynamic PET Technique. Journal of Cancer Therapy, 6, 759-766.
https://doi.org/10.4236/jct.2015.68083

has been cited by the following article:

  • TITLE: In Vitro Evaluation System of Pharmacokinetics and Irradiation Effect in Boron Neutron Capture Therapy (BNCT) Using Three-Dimensional Artificial Human Tumor Tissue Model

    AUTHORS: Shintaro Ishiyama, Yoshiya Asano, Minoru Suzuki, Mitsuru Akashi, Hiroshi Shimoda

    KEYWORDS: Boron Neutron Capture Therapy (BNCT), Boronophenylalanine (10BPA), Artificial Human Tumor Tissue Model, Cell Accumulation Method

    JOURNAL NAME: Journal of Cancer Therapy, Vol.10 No.10, October 21, 2019

    ABSTRACT: Boron neutron capture therapy (BNCT) is based on the incorporation of boron-containing drugs to cancer cells and the nuclear reaction of 10B atoms by thermal neutron irradiation results in tumor degeneration. For the development of this therapy, currently, long time and high cost consuming experiments using many animals are required. In this study, we constructed a new in vitro evaluation system for BNCT by combination of an artificial tumor tissue model, comprised of normal human dermal-derived fibroblast (NHDF) and human pancreatic cancer cell line BxPC3, and the optical plastic material CR-39 as a solid state nuclear track detector. Administration of boronophenylalanine (10BPA) as a boron-containing drug and neutron irradiation up to 2.52 × 1012 n/cm2 to the control tissue constructed by NHDF (NHDF3D) and BxPC3 cell loaded tissue (NHDF3D/BxPC3) resulted in detection of 1.6 times higher number of α-ray/recoiled Li particle tracks in NHDF3D/BxPC3 in comparison to NHDF3D, demonstrating that putative irradiation damage to cancer cells can be evaluated by this system. On a cellular level, the hit number of α-ray/recoiled Li particle tracks per single BxPC3 cells and NHDF was evaluated as 5.46 and 1.71, respectively. The tumor and normal tissue ratio (T/N ratio) was 3.19, which was corresponded with those of BPA as 2 - 4 that reported in the previous studies. This new in vitro evaluation system may provide a useful tool for a low cost, labor-saving, and non-animal method for the development of new boron-containing drugs or improvement of BNCT conditions.