TITLE:
Correlation Analysis of 5-HTTLPR Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province
AUTHORS:
Ning Bei, Min Guo, Ping Huang, Juncheng Guo, Xiangling Jiang, Hong Gao, Dengyi Long
KEYWORDS:
5-HTTLPR, Gene Polymorphism, PTSD, Li Nationality, Han Nationality
JOURNAL NAME:
World Journal of Neuroscience,
Vol.9 No.4,
October
11,
2019
ABSTRACT:
Objective: To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan
Province. Methods: Essen trauma inventory (ETI), clinician
administered post-traumatic stress disorders scale, (CAPS), tower of Hanoi
(TOH), wsiconsin card sorting test (WCST), trail making test (TMT) and wechsler
adult intelligence scale revised China (WAIS-RC) were used to
investigate patients with PTSD and healthy volunteers (control group). PCR and
PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results: The ETI score, total PTSD score and TMT time of Li
nationality patients with PTSD were significantly higher than those of Han
nationality patients with PTSD, and the IQ of comprehension and operation in
WAIS-RC was significantly lower than that of Han nationality patients with PTSD
(P HTTLPR genotype in Li nationality and Han nationality patients with PTSD were
significantly higher than those of LL genotype, and the perception, calculation
and block diagram in WAIS-RC were significantly lower than those of LL genotype
patients (P Conclusions: The SS genotype can increase the risk of PTSD in Li
nationality and Han nationality people in Hainan. LL genotype is associated
with PTSD of Li and Han nationalities in Hainan, and is an important protective
factor for PTSD of Li and Han nationalities in Hainan.