TITLE:
A Single Case of Two Synchronous Metastatic Tumours
AUTHORS:
Filipa Pereira, Tiago Alpoim, Maria Leitão, Manuela Machado
KEYWORDS:
Colon Cancer, Bladder Cancer, Multiple Primary Neoplasms Synchronous
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.8,
August
21,
2019
ABSTRACT: The incidence of multiple primary tumours increases with age and due to
multiple other factors as environmental and genetic predisposition. The authors
describe a case of a 77-year-old female patient with diagnosis in September
2009 of colon mucinous adenocarcinoma. She was submitted to surgery,
considered R1 and adjuvant chemotherapy. Six months after treatment she had
abdominal recurrence on a nodular lesion in peritoneal fat. The patient was
submitted to surgery and did multiple courses of systemic treatment. She underwent cytoreductive surgery with
hyperthermic chemotherapy, too. In December 2014 she
presented a nodular lesion on the bladder and after excision, the histology
confirmed a high-grade transitional cell carcinoma and she maintains treatment
with endovesical BCG instillations. After that, she had no evidence of
peritoneal disease progression. Besides the bad prognosis associated to peritoneal
disease, our case report describes a long survival (5 years with no disease progression)
in a patient with high risk at diagnosis to peritoneal recurrence. This case
shows the importance of multimodal approach and the impact of locoregional
treatment in localized metastatic disease.