TITLE:
Suggested Two Hypotheses on Dementia (“Anticholinergic Hypothesis” and “Cranial Skeletal Muscles Hypothesis”) and the Therapeutic Agent
AUTHORS:
Toshihiko Numazawa, Takeshi Nogawa
KEYWORDS:
Dementia, Alzheimer, Anticholinergic, Scopolamine, Methocarbamol, Ymaze, Skeletal Muscles
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.8 No.2,
June
28,
2019
ABSTRACT: The present study was conducted with the objective of further developing the cholinergic hypothesis and not using the prevalent amyloid beta plaque hypothesis or the tau protein hypothesis on dementia. The experiment was conducted on mice using anticholinergic drugs scopolamine and biperiden to investigate the root cause of dementia. First, we measured the mice serum for liquid chromatography-tandem mass spectrometry (LC-MS/MS) after administration of scopolamine and biperiden and found an accumulation of anticholinergic drugs metabolites in the body. The Y-maze test and measurement of LC-MS/MS in the cranial skeletal muscle cells showed that the Scopolamine metabolites have a significant effect on the cranial skeletal muscles, leading to the conclusion that Methocarbamol is an effective treatment for dementia.