TITLE:
Formulation and Characterization of Fenofibrate Loaded Solid Dispersion with Enhanced Dissolution Profile
AUTHORS:
Milon Kumar Ghosh, Mir Imam Ibne Wahed, Md. Ashraf Ali, Ranjan Kumar Barman
KEYWORDS:
Fenofibrate, Solid Dispersion, Dissolution, Solvent Evaporation, Carplex-80, PEG-4000
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.10 No.7,
July
31,
2019
ABSTRACT:
Fenofibrate (FF) is an
anti-hyperlipidaemic drug belonging to BCS class-II (low solubility, high permeability). Its bioavailability is
limited by the dissolution rate. This study was aimed to enhance the rate of dissolution
of poorly water soluble drug, FF. Initially, solid dispersions of fenofibrate
(SDFs) were formulated with Carplex-80 or PEG-4000 or in combination at various
weight ratios and were subjected to dissolution study. On the basis of drug release at various time intervals, the formulation producing
maximum drug concentration was evaluated
physicochemically using differential scanning calorimetry (DSC), powder X-ray
diffraction (PXRD), Fourier-transform infrared
spectroscopy (FTIR), and scanning electron microscopy (SEM). It was observed
that the peak drug concentration was obtained at 120 min of dissolution by
formulation SDF-7, which contains a mixture of Carplex-80 and PEG-4000 at
weight ratio 1:5:6 of FF:PEG-4000:Carplex-80, respectively. Thus, the extent of
drug release by SDF-7 was maximized by 2.5-fold than that of pure FF.
Physicochemical characterization revealed the reason for this increased drug release as a conversion of crystalline FF to amorphous form and ensured the chemical
compatibility among FF and carriers. The results specified the significant improvement of FF release using
solid dispersion technique.