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Konstantinides, S.V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galie` N., Gibbs, J.M.R., Huisman, M.V., Humbert, M., Kucher, N., Lang, I., Lankei, M., Lekakis, J., Maack, C., Mayer, E., Meneveau, N., Perrier, A., Pruszczyk, P., Rasmussen, L.H., Schindler, T.H., Svitil, P. and Noordegraaf, A.V. (2014) 2014 ESC Guidelines on the Diagnosis and Management of Acute Pulmonary Embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Endorsed by the European Respiratory Society (ERS). European Heart Journal, 36, 2642.
https://doi.org/10.1093/eurheartj/ehu479

has been cited by the following article:

  • TITLE: Systemic Thrombolysis for Intraoperative, High Risk Pulmonary Embolism, Clinical Case

    AUTHORS: Anna Grzanka, Pilar Reboto, Alfredo Plaza, Patricia Gaite

    KEYWORDS: Anesthesiology, Femur Fracture, Orthopedic Surgery, Thrombolysis, High Risk Pulmonary Embolism

    JOURNAL NAME: Open Access Library Journal, Vol.6 No.7, July 10, 2019

    ABSTRACT: A 68-year-old woman with intercondylar fracture of the femur suffers massive (high risk) pulmonary embolism (PE) during surgery and is suc-cessfully treated with systemic thrombolysis. After limb exsanguinations with Esmarch bandage, the patient presents with sudden oxygen desaturation (99% to 80%) with subsequent dyspnea and hypotension. She is intubated and requires continuous adrenalin perfusion while the surgery is finished and until she can be transferred to the reanimation ward. We decide to perform transthoracic echocardiogram (her general condition impedes transfer to tomography) which confirms right ventricular overload and pulmonary hypertension. These findings justify systemic thrombolysis, which is performed with good results. Surgery, and in particular orthopedic surgery, increase the risk of PE. When considering high risk PE, guidelines recommend primary reperfusion strategy through systemic thrombolysis (which can be contraindicated in surgery patients) or catheter-assisted thrombus removal (less widely available). Lately, surgical pulmonary embolectomy is being discussed as a treatment option for patients with contraindication to thrombolysis, but this practice is still uncommon.