Jollif, C.R., Cost, K.M., Stivrins, P.C., Grossman, P.P., Nolte, C.R., Franco, S.M., et al. (1982) Reference Intervals from Serum IgG, IgA, IgM, C3, C4 as Determined by Rate Nephelometry. Clinical Chemistry, 28, 126-128. - References

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Jollif, C.R., Cost, K.M., Stivrins, P.C., Grossman, P.P., Nolte, C.R., Franco, S.M., et al. (1982) Reference Intervals from Serum IgG, IgA, IgM, C3, C4 as Determined by Rate Nephelometry. Clinical Chemistry, 28, 126-128.

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KEYWORDS: Primary Immunodeficiencies, Immunodeficiency, Approach, Lymphopenia

JOURNAL NAME: Open Access Library Journal, Vol.6 No.5, May 20, 2019

ABSTRACT: Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually

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