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has been cited by the following article:

• TITLE: Oral Manifestations of Neurofibromatosis Type 1

  AUTHORS: Hafida Cherifi, Benjamin Fournier, Ariane Berdal, Blake McAlpin, Ishaï-Yaacov Sitbon, Bruno Gogly

  KEYWORDS: Neurofibromatosis Type 1, Genetic Disorder, Oral Tumor, Jaw Abnormalities, Periodontal Disease

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.9 No.1, February 18, 2019

  ABSTRACT: Neurofibromatosis type 1 (NF-1) is a common genetic disorder with a highly variable phenotype. The disease affects both proliferation and differentiation of cells of neurectodermal origin. The presence of tumors is very common like benign nodular neurofibromas. Tumors with unclear prognosis may be present like plexiform neurofibromas whose prognosis is more uncertain. While many organs exhibit pathologies, most commonly affected are the nervous system, skin, gastrointestinal tract and heart. Oral abnormalities are also very common: 72% of NF-1 patients exhibit pathologies in oral mucosa, gums, maxillary and temporomandibular joints, and teeth. The incidence of NF-1 and its relationship to the prevalence of caries have been discussed in other researches. It is known that poor oral hygiene plays a key role in the development of periodontal disease and caries. Here we review the oral manifestations of neurofibromatosis type 1 that we illustrate by a patient followed in the center of rare diseases of the hospital Henri Mondor, clinical service in which we work.