Article citationsMore>>
Traoré, Y., Dicko Traoré, F., Téguété, I., Mounkoro, N., Théra, A., Sissoko, A., Diallo, A., Dolo, T., Bagayogo, M., Djiré, Y.M., Koné, D., Doumbia, D., Koné, O., Tinfa, L., Sofara, A., Sylla, M., Traoré, M., Diop, A.B., Diop, O. and Dolo, A. (2011) Prevention of Mother to Child HIV Transmission in an African Hospital, Bamako-Mali. Mali Médical, 26, 18-22.
has been cited by the following article:
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TITLE:
The Effect of Human Immunodeficiency Virus-1 Infection on Low Birth Weight, Mother to Child HIV Transmission and Infants’ Death in African Area
AUTHORS:
Traoré Youssouf, Téguété Ibrahima, Dicko Fatoumata Traoré, Bocoum Amadou, Fané Seydou, Traoré Tidiani, Traoré Mamadou Salia, Dao Seydou, Touré Moustapha, Varol Nesrin, Dolo Amadou
KEYWORDS:
Low Birth Weight, Human Immunodeficiency Virus, Infection, Mother to Child Transmission, Newborn Death, Mali
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.2,
February
2,
2019
ABSTRACT: Background: It is yet a controversy subject whether low birth weight and infant
death are associated to human immunodeficiency virus-1 infection. Objective: To appreciate association between low birth weights, mother to child HIV
transmission and infant mortality in HIV-1 infected pregnant women delivering
between 2011 and 2016. Materials: We conducted 6 years cohort study in
urban Mali. Outcome included preterm delivery, small for gestational age,
infant survival status and HIV transmission. Comparison concerned women
clinical WHO stage, mother viro-immunological status, and newborn anthropometric parameters. Results: HIV-1 infected women
who delivered low birth weight newborn were 20.9% (111/531) versus 16.5%
(1910/11.546) in HIV negative patients (p = 0.016). CD4 T cell counts low than
350 T cells count were strongly associated to LBW (p = 0.000; RR = 3.03; 95% CI [1.89 - 3.16]).
There is no significant association between ART that was initiated during
pregnancy (p = 0.061, RR = 0.02; CI 95% (1.02 - 1.99)) or during delivery (p =
0.571; RR = 1.01; CI 95% (0.10 - 3.02)) and LBW delivery. In multivariate
analysis ART regimens containing protease inhibitor (PI) were lone regimens
associated with LBW ((p = 0.030; RR = 1.001; 95% confidence interval [1.28 - 3.80]).
Very low birth weight was statistically associated to women HIV infection
(adjusted relative risk, 2.02; p = 0.000; 95% confidence interval (2.17 - 4.10)). There is no
significant difference between mother to child HIV transmission rate in the two
HIV-infected pregnant women (10 infected children in group 2: MTCT rate 4.5%)
and 3 infected children in group 1 (MTCT rate: 2.7%) (p = 0.56; RR, 0.59; CI 95% (0.18 - 4.39)). In multivariate analysis, LBW was
associated with infant death (p = 0.001; RR = 2.04; CI 95% [1.04 - 5.05]). The median weight of infant at the moment of death in
group 1 was 851 g (IQR: 520 - 1833 g). Significant relationship was found
between infant death among LBW newborn with mother WHO stage 2 (p = 0.004; adjusted RR = 3.22; CI 95% [2.25 - 6.00]), CD4 T cells count
3 (p = 0.005; RR = 2.81; CI 95% [1.20 - 4.11]), PI
regimens (p = 0.030; RR = 1.00; CI 95% [1.28 - 3.80]). Conclusion: We confirm
increased risk of low birth weight and mother HIV-1 infection and we identified
strongest association between mortality in infant born to HIV-1 infected mother
and LBW.
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