TITLE:
Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis
AUTHORS:
Gao-De Li
KEYWORDS:
Chromatin Configuration, Oncogenesis, 3D Genome, Cancer, Cell Differentiation, Cell Cycle, Gene Regulation, Gene Activity
JOURNAL NAME:
Open Access Library Journal,
Vol.6 No.2,
February
1,
2019
ABSTRACT: More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.