TITLE:
Subjective Lowering of Preprandial Blood Glucose and Cancer Prevention by Planning and Recognizing Initial Hunger
AUTHORS:
Mario Ciampolini
KEYWORDS:
Blood Glucose, Diabetes, Insulin Resistance, Overweight, Fattening, Energy Balance, Energy Intake, Limit in Energy Intake, Hunger, Meal Onset, Energy Availability, Malignant Diseases, Bowel Disorders, Malnutrition, Cancer
JOURNAL NAME:
Open Journal of Preventive Medicine,
Vol.9 No.1,
January
31,
2019
ABSTRACT: We recently described the training of the passage from scheduled to demanded
meals in infants and adults. Subjects reduced energy intake by subjectively
abolishing conditioned meals and by allowing intake only after demand
by the infant or after hunger perception by the adult (Initial Hunger
Meal Pattern; IHMP). Conditioned meals were those scheduled and/or presented
to the infant as well to the adult by sight, smell, mentioning, gesturing
or simply at a fixed mealtime. During IHMP instead, meals were suspended
until the first infant’s demand or until an adult’s self-noticing arousal of
hunger. IHMP was checked by measuring blood glucose before three meals
per day (MBG) and was associated with significant decreases in diary-reported energy-intake, MBG, glycated hemoglobin, body weight, insulin
AUC in glucose tolerance tests and in days with diarrhea as compared to
randomized control subjects who maintained conditioned meals. Although
generalized, conditioned eating is a modern aberration that is associated with
development of insulin resistance and overall inflammation. These associations
are well demonstrated independently from the implicated mechanism.
A state of Overall Subclinical Inflammation greatly increases cell and DNA
replications and replication errors. After decades of DNA errors, oncogenic
cells arise and cumulate. A prevention of malignancies is possible by interrupting
the development of conditioned eating, insulin resistance and associated
overall inflammation.