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https://doi.org/10.1016/S0018-506X(02)00016-8

has been cited by the following article:

• TITLE: Functional Change of Brain Serotonergic Activity and Free Tryptophan in the Plasma of Depressed Women

  AUTHORS: Felipe Vázquez-Estupiñan, Rocío Herrera-Márquez, José Antonio Mondragón-Herrera, Guillermina Lara-Pérez, Gabriel Manjarrez-Gutiérrez

  KEYWORDS: Depression, Auditory-Evoked Potential (N1/P2) Component, Brain, Serotonin, L-Tryptophan

  JOURNAL NAME: Open Journal of Depression, Vol.8 No.1, January 17, 2019

  ABSTRACT: The main objective was to show the decrement of serotoninergic brain activity in depressed women, through the analyses of the slope amplitude of N1/P2 components of the auditory-evoked potentials (AEP), and the measurement of the L-tryptophan free fraction in plasma (FFT). This cross-sectional study was carried out in 60 women, 30 depressed and 30 normal controls. Both groups were measured FFT, glucose, and neutral amino acids (NAA) levels; besides performing AEP to analyses the N1/P2 slope amplitude. It was found a lengthening in the slope amplitude of N1/P2 components of AEP in the group of depressed women, and despite that the level of FFT was low, there were no changes between bound fraction and the total L-Trp. The former suggests a decrease in serotonergic brain activity in the group of depressed women. Otherwise, since the auditory cortex response to sound is regulated by serotonergic innervation, it was expected a change in the behavior of AEP in the group of depressed patients. Thus, the slope amplitude of N1/P2 components of the AEP and the measurement of FFT have proved to be a good clinical indicators of the serotonergic neurotransmission state in the brain of depressed patients, and in another clinical conditions where brain serotonin is involved.