TITLE:
Prognostic Significance of Comparison of Clinical Indicators with Manifestations of Genetic Polymorphism of Glutathione-S-Transferases in Non-Small Cell Lung Cancer
AUTHORS:
Mikhail N. Shapetska, Evelina V. Krupnova, Alena P. Mikhalenka, Natalia V. Chebotareva, Anna N. Shchayuk, Svetlana G. Pashkevich, Alexander V. Prokhorov
KEYWORDS:
Squamous Cell Lung Carcinoma, Adenocarcinoma, Glutathione-S-Transferase, Survival Rate
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.12,
December
11,
2018
ABSTRACT: The article presented the results of comparison of polymorphic variants of the genes
GSTM1, GSTT1, GSTP1 and clinical manifestations of non-small cell lung
carcinoma. The association of the genotype GSTT1 (del) with the risk of
developing squamous cell lung cancer has been revealed (OR = 2.54 CI: 1.13 - 5.72, p = 0.035). Analysis of patient survival rate (n = 173) in groups
of various histological types of lung cancer showed that in the group of
squamous cell lung cancer (n = 91) in patients with genotype GSTT1 (del), the
survival rate median was significantly higher—84 months (95% CI 12.4 - 155.7)
than in patients with the genotype GSTT1 (+)—36 months (95% CI 25.2 - 46.8, p =
0.045). In contrast, in the adenocarcinoma group (n = 82), the survival rate
median in patients with the genotype GSTT1 (del) was 19 months. (95% CI 6.2 - 33.5), and in patients with genotype GSTT1 (+)—67
months (95% CI 50.1 - 84.0), which is the basis for continuing this comparison
in an additional group of testees, as the sampling did not achieve the
reliability of p = 0.12. Hypothetically, these differences may be due to differences
in the gender composition of squamous cell lung cancer and adenocarcinoma and
the involvement of GST enzymes in the metabolism of estrogens in adenocarcinoma in women and other hormonal background and reactivity
of the male body with squamous cell carcinoma. Further research and subsequent
analysis of the results will be aimed at confirming this hypothesis.