TITLE:
Accelerated Hyper Fractionated Radiotherapy in Localized Ewing’s Sarcoma with or without Surgery: What’s New? A Phase II Study
AUTHORS:
Amal Rayan, Ahmed Soliman, Khalid F. Riad, Asmaa M. Zahran, Hosam A. Hasan
KEYWORDS:
Accelerated Hyper Fractionated RT, Ewing’s Sarcoma, Relapse Free Survival
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.10,
October
29,
2018
ABSTRACT: Background and aim of work: We aimed from this study to determine the response and local relapse
free survival (RFS) of pediatric patients with localized Ewing’s sarcoma
treated with accelerated hyper-fractionated
RT. Patient and methods: This study was a nonrandomized
uncontrolled phase II study and was conducted at clinical oncology department
and south Egypt cancer institute; it involved 28 patients with histologically
confirmed Ewing’s sarcoma; all of them were subjected to PET/CT whenever
possible or MRI with contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the
protocol of accelerated hyper fractionated RT. Results: The overall
response rate (ORR) was 92.9% by MRI with significant effect of the type of
response on local RFS (P 0.002). The median local RFS of 28 patients with localized
Ewing’s sarcoma was 30 ± 8.599 months with 95% CI = 13.147 - 46.853; the 3-year local control was 35%. Conclusion: Accelerated hyper fractionated RT didn’t achieve better results than standard
fractionation RT, but it is recommended to be done on a large sample
size, and multiple centers, and continued follow up is also recommended to evaluate 5-year LRFS, 5-year OS.