Nguyen, L.T. and Ohashi, P.S. (2015) Clinical Blockade of PD1 and LAG3—Potential Mechanisms of Action. Nature Reviews Immunology, 15, 45-56.
https://doi.org/10.1038/nri3790

has been cited by the following article:

• TITLE: Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology

  AUTHORS: Tania Rahman, Md. Ferdous Seraj, Annelise Casellato

  KEYWORDS: Regulatory T Cells, Foxp3, tTreg, pTreg, IL-10, TGF-β, Helios, Neuropilin-1

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.9 No.9, September 18, 2018

  ABSTRACT: Regulatory T cells (Treg), a component of adaptive immunity, are well known for their immunosuppressive roles and their ability to maintain the balance between the immunological and pathological reactions. Treg have been shown to provide protective responses and their depletion has resulted severe pathology in some pathogen infections. The work presented here has unravelled the potential of regulatory cells in the immune system including different repertoir of Treg cell subsets, markers to distinguish them, Treg suppression mechanisms in the pathogenesis of various infections and summarize different mouse models depleting Tregs. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights for pathogenesis and also for broader antibacterial/antiviral/antiproliferative immunity.