TITLE:
Study of Angiotensin Converting Enzyme Gene Polymorphism in Egyptian Type 2 Diabetes Mellitus with Diabetic Kidney Disease
AUTHORS:
Rizk A. El-baz, Alaa M. Wafa, El-Shaimaa Marrawan, Ahmed Ragab A. El-Tawab, Zeinab Ibraheam Aly
KEYWORDS:
ACE Gene Polymorphism, Insertion/Deletion, Type 2 Diabetes Mellitus, T2DM, Diabetic Kidney Disease, Diabetic Nephropathy, Microvascular Complications of Diabetes Mellitus
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.9 No.8,
August
7,
2018
ABSTRACT: Objective: Diabetic kidney disease DKD (Diabetic nephropathy DN) is considered one of the chronic micro vascular complications of diabetes mellitus and considered the commonest cause leading to chronic renal failure and chronic renal dialysis. Genetic susceptibility has been implicated in DKD. The angiotensin converting enzyme (ACE) is one of the key roles in the renin angiotensin system cascade by converting angiotensin I to angiotensin II which plays a key role in regulation of blood pressure as well as electrolytes and fluid balance. This study addressed the association of (ACE) gene polymorphisms with DN in Egyptian (T2DM) patients. Methods: Our research comprised of 75 cases of T2DM with diabetic kidney disease, 100 cases of T2DM without DKD and 94 healthy volunteers. Different genotypes of ACE gene were determined by SSP-PCR analysis. Results: Gene polymorphism of ACE (DD, ID, II) in diabetic patient with DKD is 44%, 52%, 4% respectively and for T2DM individuals without DKD is 23%, 72%, 5% respectively. (DD) had significant higher frequencies in T2DM patients with DKD compared to those without DKD (p