TITLE:
Relationship between Obesity, Serum Uric Acid, Serum Potassium and Glomerular Filtration Rate with Electric Left Ventricular Hypertrophy in Blacks Central Africans with High Blood Pressure
AUTHORS:
Bertrand Fikahem Ellenga Mbolla, Paul Macaire Ossou Nguiet, Richard Loumingou, Meo Stéphane Ikama, Narcisse Ngangoue, Thierry Raoul Gombet, Henri Germain Monabeka, Benjamn Longo Mbenza, Gisèle Kimbally Kaky
KEYWORDS:
Obesity, High Blood Pressure, Glomerular Filtration Rate, Uric Acid, Serum Potassium, Black African
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.8 No.4,
April
30,
2018
ABSTRACT: The authors conducted a retrospective study over a period of 6 months in a hypertensive population in order to determine the correlation between serum uric acid on glomerular filtration rate (GFR) and estimated serum potassium with left ventricular hypertrophy (LVH) and obesity. This study enrolled 122 patients including 63 women (51.6%). The mean age was 55.9 ± 10.6 years (range 30 to 74 years). Obesity weight was found in 38 cases (31.1%) of which 20were men (33.9%) and 18 women (28.6%). Abdominal obesity was found in 104 cases (85.2%). The average serum uric acid in patients with obesity weight was 63.3 ± 18.9 mg/L vs 62.4 ± 14.2 mg/L for no-obese patients (p= 0.63). The average serum potassium in obese patients was 4.06 ± 0.42 mEq/L vs 4.02 ± 0.46 mEq/L for no-obese (p= 0.65). The average GFR was 73.4 ± 21.4 ml/L in obese patients vs 66.6 ± 22.6 ml/min in no-obese (p= 0.03). The LVH was found in 81 cases (66.4%). The LVH was found in 65 (62.5%) obese patients vs16 (88%) non-obese patients (OR = 4.8, 95% 1.04-22p= 0.02). Only abdominalobesity has been correlated with left ventricular hypertrophy after multivariate analysis. Emphasis must be focused on public health actions for effective and appropriate measures against obesity and hypertension, whose prevalence is increasing in our region.