Manuel, D.-D. (2007) Efficacy and Satisfaction with the Firmness of the Erection with Rapid Scaling of the Dose of Sildenafil 50 to 100 mg in Men with Erectile Dysfunction. Mexican Journal of Urology, 67, 35-48.

has been cited by the following article:

• TITLE: Efficacy and Safety Evaluation of Sildenafil Citrate in the Form of 50 mg Orodispersible Tablets Controlled by Placebo

  AUTHORS: Maria Antonieta Annunziato, Di Capua Teodoro, Dieguez Vicente, Ledos Luis, Koury Mufid

  KEYWORDS: Erectile Dysfunction, Sildenafil, Orodispersable Tablets

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.7 No.3, March 23, 2018

  ABSTRACT: Purpose: To evaluate the efficacy and safety of sildenafil in orodispersable tablets of 50 mg vs. placebo in men with erectile dysfunction (ED). Methods: A blind, comparative, placebo controlled, randomized study was developed in 106 patients with ED. They randomly received sildenafil orodispersable 50 mg (Group I) or placebo (Group II) 3 times per week, 1 hour before sexual activity, during 4 weeks. The efficacy was evaluated by IIEF-5 and the adverse events (AE) by poll. Results: After 4 weeks a percentage improvement of the ED was observed in Group I patients 44% of whom became without ED vs. 2% of Group II, with an additional statistical significant improvement evidenced respect to the placebo in the IIEF-5 score from 13.7 ± 4.9 to 19.9 ± 4.4 vs. 13.1 ± 4.0 to 17.8 ± 4.9 in the placebo group, Confidence Interval (CI95%): 19.90 vs. 13.98, respectively, p Conclusions: Sildenafil was superior to placebo, substantially improved the IIEF-5 scores, showing a statistical significant therapeutic response in the ED treatment and it was safe and well tolerated.