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Hin, N., Duvall, B., Ferraris, D., Alt, J., Thomas, A.G., Rais, R., Raja, C., Wu, Y., Wozniak, K.M., Slusher, B.S. and Tsukamoto, T. (2015) 6-Hydroxy-1,2,4-Triazine-3,5-(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors. Journal of Medicinal Chemistry, 58, 7258-7272.
https://doi.org/10.1021/acs.jmedchem.5b00482
has been cited by the following article:
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TITLE:
Synthesis of New Fluorinated Fused Heteropolycyclic Nitrogen Systems Containing a Pyrazolotriazine Moiety as Antimicrobial Agents Part I
AUTHORS:
Layla A. Taib, Sofiyah A. Adibani
KEYWORDS:
Synthesis, Fluoro-Fused Heterocyclic Systems, Antimicrobial Agents
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.1,
March
22,
2018
ABSTRACT: A simple route to synthesize novel fluorinated fused hetero-polycyclic nitrogen systems containing a pyrazolotriazine moiety (5,8,11) have been deduced from cyclization of 2-aminothiocarbonyl-5-arylidene-3-phenyl-1,2,4-triazin-6(1H)one (2) with diethoxy-phosphine, diethyl carbonate and/or diethyl oxalate in boil THF followed by cyclo condensation with aryl sulfonic acid hydrazide in EtOH/piperidine and finally fluorination with trifluoroethyl acetate. Structures of the products have been established from their elemental analysis and spectral measurements. The antimicrobial activity of the targets has also been evaluated.
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DOI:
10.4236/ojpc.2011.13016
3,557 Downloads 6,397 Views Citations
Pub. Date:
November
25,
2011
